解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The very late antigens (VLAs) are alpha beta-heterodimeric transmembrane proteins that include surface cell receptors for laminin (VLA-6) and collagen (VLA-2), which mediate cell-matrix and cell-cell adhesion. We investigated the distribution of VLA-6 (alpha 6, beta 1) and VLA-2 (alpha 2, beta 1) proteins in normal, h...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90033-d
更新日期:1993-03-01 00:00:00
abstract::The presence of thyroglobulin (TG) was investigated by immunohistochemistry with one polyclonal and three distinct monoclonal anti-TG antibodies in 19 primary and 15 metastatic medullary thyroid carcinoma (MTC) cases. In two primary tumors possessing a mixed trabecular and follicular growth pattern, a significant numb...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90035-f
更新日期:1993-03-01 00:00:00
abstract::We developed a procedure based on computerized image analysis to establish objective criteria for the differential diagnosis between mesothelial hyperplasia and cancer in peritoneal tissue samples obtained at second-look operations for ovarian cancer. The tumor tissue after chemotherapy was classified as "nonresponsiv...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90292-o
更新日期:1993-02-01 00:00:00
abstract::Twenty-two consecutive cases of adenoma in acromegalic patients were studied immunohistochemically. All the tumors contained prolactin (PRL)-reactive cells (3% to 53% of the total number of tumor cells) as well as growth hormone (GH)-reactive cells (4% to 74% of the total number of tumor cells). All acromegalic cases ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90056-m
更新日期:1993-01-01 00:00:00
abstract::A case of myocardial hyperplasia with numerous mitotic figures, caterpillar nuclei, and an abnormal DNA ploidy pattern is described in an 8-day-old full-term baby with uneventful gestation and sudden death. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90064-a
更新日期:1992-12-01 00:00:00
abstract::Although all carcinoid tumors are considered potentially malignant, the biologic behaviors of appendiceal and ileal carcinoids are distinctly different. Appendiceal carcinoids often behave in a benign fashion, whereas ileal carcinoids pursue an aggressive course with frequent metastasis. Whether differences in DNA plo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90052-5
更新日期:1992-12-01 00:00:00
abstract::We report the morphonuclear characteristics of normal (13 cases), benign (ie, chronic) pancreatitis (six cases), and neoplastic (ie, ductal) adenocarcinoma (22 cases) tissues of the pancreas. This description is based on computerized cell image analysis, which permits the determination of parameters related to the mor...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90287-d
更新日期:1992-11-01 00:00:00
abstract::Benign lymphocytic angiitis and granulomatosis is a T-cell lymphoproliferative disorder confined to the lung and corresponding to a low-grade angiocentric immunoproliferative lesion. Controversy remains as to whether these lesions are lymphomas. We report such a case in an 8-year-old patient with Burkitt's lymphoma in...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90041-z
更新日期:1992-10-01 00:00:00
abstract::The neuropathologic findings in the spinal cord were reviewed in 138 consecutive autopsies of patients with the acquired immunodeficiency syndrome. In all cases both the brain and spinal cord were examined by conventional histologic techniques, and in 63 cases immunohistochemistry was used to detect human immunodefici...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90028-2
更新日期:1992-10-01 00:00:00
abstract::A 48-year-old man with a history of recurrent urolithiasis and chronic renal failure underwent a nephrectomy for a renal mass. At surgery the mass proved to be a calculus impacted in a dilated calyx. Gross examination of the kidney revealed chalky white deposits in the deep medulla and papillary tips. Histologic exami...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90273-6
更新日期:1992-09-01 00:00:00
abstract::A cytogenetic study of an eccrine spiradenoma and two lymph node metastases, with a growth pattern and microscopic appearance typical for benign eccrine spiradenoma, revealed a 46,XY-5,del(16)(q22),+mar(t(?;5)(?::5q13----5qter)) karyotype. The finding of the same abnormal karyotype in the tumor and the metastases sugg...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90274-7
更新日期:1992-09-01 00:00:00
abstract::Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examina...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90401-n
更新日期:1992-08-01 00:00:00
abstract::Oral contraceptive-associated sinusoidal ectasia is a rare lesion of unknown pathogenesis. We describe the case of a 31-year-old woman who had used oral contraceptives for 10 years and was found to have abnormal liver function tests on "routine" examination. A single 9 x 5 x 4 cm hypervascular lesion was demonstrated ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90411-u
更新日期:1992-08-01 00:00:00
abstract::The histogenesis of colloid cysts (CCs) of the third ventricle has been a subject of controversy. We examined, using immunohistochemical techniques, four CCs for the presence of cytokeratins (CKs), glutathione S-transferase isoenzymes (GST-pi, GST-mu), and glial fibrillary acidic protein. Antibodies to both low molecu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90352-4
更新日期:1992-07-01 00:00:00
abstract::The DNA content and proliferative indexes of seven cases of tenosynovial giant cell tumor of tendon sheath, diffuse type (TGCT-D); 11 cases of tenosynovial giant cell tumor of tendon sheath, localized type (TGCT-L); and seven cases of pigmented villonodular synovitis (PVNS) were analyzed by flow cytometry in an attemp...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90340-9
更新日期:1992-07-01 00:00:00
abstract::Sneddon's syndrome is a potentially fatal arterio-occlusive disorder characterized by generalized livedo racemosa and cerebrovascular lesions. Skin biopsies often fail to yield diagnostic arterial lesions. In the present series, affected vessels were found in skin biopsies from 12 of 15 patients with Sneddon's syndrom...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90323-u
更新日期:1992-06-01 00:00:00
abstract::A digoxigenin-tailed, synthetic oligodeoxynucleotide was used to detect genomic hepatitis delta virus (HDV) RNA in formalin-fixed, paraffin-embedded liver sections by a nonisotopic in situ hybridization (NISH) procedure. Twenty-three liver samples from chronically HDV-infected patients were studied. Eight liver specim...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90133-n
更新日期:1992-05-01 00:00:00
abstract::Hydatidiform moles are classified as partial or complete by histologic criteria (Am J Obstet Gynecol 131:665-671, 1978 and Am J Obstet Gynecol 132:20-27, 1978). While persistent gestational trophoblastic tumors follow both types, there remains controversy as to whether the malignant extreme of gestational trophoblasti...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90096-l
更新日期:1992-04-01 00:00:00
abstract::Endocrine-paracrine (APUD, neuroendocrine) cells are located in the prostatic ductal and acinar epithelium. These cells are of the open and closed type and have dendritic processes. There is a wide range of secretory granule morphology presumably indicating a variety of different cell "types." Secretory immunoreactive...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(92)90110-o
更新日期:1992-03-01 00:00:00
abstract::Kaposi's sarcoma (KS) is a pleomorphic spindle cell lesion whose incidence has markedly increased among patients infected with the human immunodeficiency virus (HIV), especially among those whose primary risk factor is homo/bisexual transmission. The question as to whether KS is even a true neoplasm still remains larg...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90112-g
更新日期:1992-03-01 00:00:00
abstract::Human papillomavirus (HPV) types 16 and 18 are strongly implicated in the generation of progressive cervical neoplasms. The viruses produce complex families of overlapping messenger RNAs that are linked to differentiation, making it necessary to analyze gene expression in the context of morphology. We have developed H...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90232-r
更新日期:1992-02-01 00:00:00
abstract::The clinical and pathologic features of 15 new cases of the uncommon primary or granulomatous angiitis of the central nervous system (PACNS) are described. To date, only 108 such cases have been reported in the English literature. Clinically, most PACNS patients have been young or middle-aged (mean age, 45 years; rang...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(92)90238-x
更新日期:1992-02-01 00:00:00
abstract::We treated 36 women with laparoscopically proven endometriosis with danazol 600 mg/d (n = 17) or gestrinone 5.0 mg/wk (n = 19) for 6 months. Endometrial samples were obtained before and at 3 and 6 months of treatment and were studied by light, scanning, and transmission electron microscopy. At 3 months of treatment, t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90011-q
更新日期:1992-01-01 00:00:00
abstract::We report two cases of allergic bronchopulmonary fungal disease (ABPFD) caused by Curvularia sp and associated with allergic fungal sinusitis (AFS). Curvularia lunata was cultured in one case and Curvularia senegalensis was cultured in the other. Based on these cases and a review of the literature, we discuss unusual ...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(91)90106-y
更新日期:1991-12-01 00:00:00
abstract::Pleomorphic adenomas of the breast (PAB) are uncommon tumors. We studied the clinicopathologic features of 10 cases of PAB, seven of which were assessed immunohistochemically. Nine patients were women, with a median age at diagnosis of 65 years. Eight patients presented with a palpable mass; two had a nipple discharge...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(91)90102-u
更新日期:1991-12-01 00:00:00
abstract::Angiocentric immunoproliferative lesions (AILs) are believed to represent a unique type of extranodal malignant lymphoma on the basis of clinicopathologic and immunophenotypic evidence. However, molecular studies to assess clonality have been performed on a small number of cases. In this study we assessed the clonalit...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90269-u
更新日期:1991-11-01 00:00:00
abstract::The shortage of pathologists is being created by a combination of three factors: inadequate trainee recruitment, high trainee attrition, and accelerating practitioner attrition. The current report provides comprehensive data on the first two factors. The third factor is, by every estimate, likely to become worse over ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90258-q
更新日期:1991-11-01 00:00:00
abstract::The previously unreported association of granulomatous gastritis and mononeuritis multiplex occurring in the setting of a vasculitic syndrome is described. The two conditions are considered to be associated and to be immune mediated. The previously accepted concept of isolated granulomatous gastritis is disputed. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90018-k
更新日期:1991-10-01 00:00:00
abstract::Twenty-five uterine stromal neoplasms (five stromal nodules and 12 low-grade and eight high-grade stromal sarcomas) were studied to determine the correlation between clinicopathologic features, flow cytometric tumor DNA content and proliferative fraction, and patient outcome. Fifteen of the 20 sarcomas (five of them h...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90179-s
更新日期:1991-09-01 00:00:00
abstract::Atypical mesothelial hyperplasia encountered in pleural fluid or in a pleural biopsy specimen raises the suspicion that one may be dealing with a diffuse malignant mesothelioma of the pleura. We studied eight cases with cytologic or histologic changes of mesothelial atypia thought to be suspicious for diffuse malignan...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90292-w
更新日期:1991-07-01 00:00:00
abstract::Neuronal intranuclear inclusion disease (NIID) is a progressive, usually fatal degenerative neurologic condition characterized by eosinophilic, intranuclear inclusions in neurons of the central and peripheral nervous system. We report a boy with onset of disease manifestations at age 3 and death at age 9, who showed c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90296-2
更新日期:1991-07-01 00:00:00
abstract::One hundred cases of invasive breast carcinoma were studied using the commercially available monoclonal antibody Anti-Human Tumor-Associated Glycoprotein-72 (MAb B72.3, Biomedical Technologies Inc, Stoughton, MA) prediluted at 8.5 micrograms/mL. Forty-three cases displayed positive reactivity with this antibody. Inten...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90238-k
更新日期:1991-06-01 00:00:00
abstract::Adenomatous hyperplasia, a hyperplastic parenchymal nodule in the cirrhotic liver, has been presumed to be a preneoplastic lesion in human hepatocarcinogenesis. In this study, phenotypes of the sinusoidal endothelium were examined in adenomatous hyperplasia, hepatocellular carcinoma, cirrhosis, chronic active hepatiti...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90136-d
更新日期:1991-05-01 00:00:00
abstract::Women with breast cancer have an increased risk of developing primary ovarian tumors. Because a differential diagnosis between primary and metastatic tumors may be difficult in poorly differentiated ovarian neoplasms, breast carcinoma markers may be helpful in establishing the primary site of origin. Gross cystic dise...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90084-3
更新日期:1991-04-01 00:00:00
abstract::Dysplastic nevi are an important indicator of risk of cutaneous malignant melanoma. The study of and, particularly, international communication regarding this group of lesions have been hindered by a lack of precision in diagnosis. In an effort to broaden understanding, a panel of pathologists agreed upon a set of cri...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90078-4
更新日期:1991-04-01 00:00:00
abstract::Small-cell osteosarcoma is a rare form of osteosarcoma and often poses difficulty in differential diagnosis when tissue samples do not include any diagnostic osteoid. By light microscopy, it may be difficult to distinguish small-cell osteosarcoma from other small-cell neoplasms, especially Ewing's sarcoma and mesenchy...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90161-h
更新日期:1991-03-01 00:00:00
abstract::Mucus-filled cystic tumors of low or borderline malignant potential, well recognized in ovary and appendix, have received little attention in the lung. We present data on 11 patients, all of whom had solitary pulmonary nodules resected in which mucus was the major histologic component. Prognosis appears good; no patie...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90041-m
更新日期:1991-02-01 00:00:00
abstract::In order to study the granular transformation of Sertoli cells the following testicular specimens were reviewed: 58 postmortem biopsies from 21 children and 37 young adult males with normal histologic pattern; 165 biopsies from prepubertal cryptorchid testes; 38 biopsies and 18 surgical specimens from postpubertal-cry...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90034-m
更新日期:1991-02-01 00:00:00
abstract::We studied renal tissues from 203 patients with acquired immunodeficiency syndrome (AIDS). Of the 203 patients, 20 showed light-microscopic changes characteristic of AIDS-associated nephropathy (AAN). Fifteen of the 20 (group A) were examined by immunohistochemistry using Mycoplasma fermentans (incognitus strain)-spec...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90063-u
更新日期:1991-01-01 00:00:00
abstract::Ten cases of reactive follicular hyperplasia and 31 cases of B-cell non-Hodgkin's malignant lymphoma were studied using multiparameter flow cytometry. A bimodal distribution for HLA-DR expression, but not for surface immunoglobulin or B cell-specific antigens CD19 and CD20, was observed commonly in mixed cell type and...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(06)80042-0
更新日期:1990-12-01 00:00:00